VAST systems are increasingly being used as the foundation of healthcare and life sciences infrastructure where data and AI are central to advancing research and patient care. This session highlights two related case studies. University of Rochester Medical Center explores new methods of enhancing patient care and hospital productivity while concurrently servicing the needs of medical researchers and clinicians as AI and regulated data combine to find new discoveries. Purdue discusses their partnership with leading pharmaceutical companies and the infrastructure required to power drug discovery, reviewing how VAST DataEngine can bring data processing automation and simplicity to previously complex pipelines.